ACADEMIC RECORD

PUBLICATIONS

_PUBLICATIONS

2026

Spatial metabolomics and multiomics integration for breakthroughs in precision medicine for kidney disease

Sharma K, Hansen J, Susztak K, Eberlin L, Anderton CR, Alexandrov T, Iyengar R.

Nat Rev Nephrol. 2026 Feb;22(2):152-164.

PMID: 41068470

2025

Overview: Spatial Metabolomics Review Series

Sharma K, Iyengar R.

Semin Nephrol. 2024 Nov;44(6):151576.

PMID: 40199630

National Cancer System Characteristics and Prostate Cancer Outcomes: An Analysis of Global Data

Dee EC, Iyengar R, Narayan A, Feliciano EJG, Wu JF, Ho FDV, Ng K, Willmann J, Cabaero MLL, Tan AKNG, Lapen K, Gorovets D, Rathkopf DE, McBride SM, Nagar H, Mahal BA, Nguyen PL.

Prostate. 2025 Jul;85(10):947-953.

PMID: 40235173

Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data

Vidović D, Shamsaei B, Schürer SC, Kogan P, Chojnacki S, Kouril M, Medvedovic M, Niu W, Azeloglu EU, Birtwistle MR, Chen Y, Chen T, Hansen J, Hu B, Iyengar R, Jayaraman G, Li H, Liu T, Sobie EA, Xiong Y, et al.

Mol Cell Proteomics. 2025 Jul;24(7):100947.

PMID: 40089066PMCID: PMC11246342

Ontology-based modeling, integration, and analysis of heterogeneous clinical, pathological, and molecular kidney data for precision medicine

He YO, Barisoni L, Rosenberg AZ, Robinson P, Diehl AD, Chen Y, Phuong J, Hansen J, Herr Ii BW, Börner K, Schaub J, Bonevich N, Arnous G, Boddapati S, Zheng J, Alakwaa F, Sardar P, Duncan WD, Liang C, Valerius MT, Jain S, Iyengar R, Himmelfarb J, Kretzler M; Kidney Precision Medicine Project.

AMIA Annu Symp Proc. 2025 May 22;2024:523-532.

PMID: 40417545PMCID: PMC11116234

2024

Multiscale mapping of transcriptomic signatures for cardiotoxic drugs

Hansen J, Xiong Y, Siddiq MM, Dhanan P, Hu B, Shewale B, Yadaw AS, Jayaraman G, Tolentino RE, Chen Y, Martinez P, Beaumont KG, Sebra R, Vidovic D, Schürer SC, Goldfarb J, Gallo JM, Birtwistle MR, Sobie EA, Azeloglu EU, Berger SI, Chan A, Schaniel C, Dubois NC, Iyengar R.

Nat Commun. 2024 Sep 11;15(1):7968.

PMID: 39261481PMCID: PMC11390492

Integrating Metabolomics and Transcriptomics to Characterize Differential Functional Capabilities of Kidney Proximal Tubule Cell Subtypes

Hansen J, Siddiq MM, He JC, Iyengar R.

Semin Nephrol. 2024 Nov;44(6):151577.

PMID: 40180882

Pharmacology of boldine: summary of the field and update on recent advances

Sáez JC, Burrell JC, Cahill CM, Cullen DK, Devi LA, Gilbert RJ, Graham ZA, Gurvich VJ, Havton LA, Iyengar R, Khanna R, Palermo EF, Siddiq M, Toro CA, Vasquez W, Zhao W, Cardozo CP.

Front Pharmacol. 2024 Sep 13;15:1427147.

PMID: 39346563PMCID: PMC11430043

From transcriptomics to digital twins of organ function

Hansen J, Jain AR, Nenov P, Robinson PN, Iyengar R.

Front Cell Dev Biol. 2024 Jun 26;12:1240384.

PMID: 38989060PMCID: PMC11234053

2023

Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients

Sharma K, Zhang G, Hansen J, Bjornstad P, Lee HJ, Menon R, Hejazi L, Liu JJ, Franzone A, Looker HC, Choi BY, Fernandez R, Venkatachalam MA, Kugathasan L, Sridhar VS, Natarajan L, Zhang J, Sharma VS, Kwan B, Waikar SS, Himmelfarb J, Tuttle KR, Kestenbaum B, Fuhrer T, Feldman HI, de Boer IH, Tucci FC, Sedor J, Heerspink HL, Schaub J, Otto EA, Hodgin JB, Kretzler M, Anderton CR, Alexandrov T, Cherney D, Lim SC, Nelson RG, Gelfond J, Iyengar R; Kidney Precision Medicine Project.

J Clin Invest. 2023 Oct 16;133(20):e170341.

PMID: 37616058PMCID: PMC10578964

FN (Fibronectin)-Integrin α5 Signaling Promotes Thoracic Aortic Aneurysm in a Mouse Model of Marfan Syndrome

Chen M, Cavinato C, Hansen J, Tanaka K, Ren P, Hassab A, Li DS, Youshao E, Tellides G, Iyengar R, Humphrey JD, Schwartz MA.

Arterioscler Thromb Vasc Biol. 2023 May;43(5):e132-e150.

PMID: 36994727PMCID: PMC10151187

Spinal cord injury regulates circular RNA expression in axons

Siddiq MM, Toro CA, Johnson NP, Hansen J, Xiong Y, Mellado W, Tolentino RE, Johnson K, Jayaraman G, Suhail Z, Harlow L, Dai J, Beaumont KG, Sebra R, Willis DE, Cardozo CP, Iyengar R.

Front Mol Neurosci. 2023 Aug 24;16:1183315.

PMID: 37692100PMCID: PMC10486858

A spatially specified systems pharmacology therapy for axonal recovery after injury

Siddiq MM, Johnson NP, Zorina Y, Yadaw AS, Toro CA, Hansen J, Rabinovich V, Gregorich SM, Xiong Y, Tolentino RE, Hannila SS, Kaplan E, Blitzer RD, Filbin MT, Cardozo CP, Passaglia CL, Iyengar R.

Front Pharmacol. 2023 Sep 20;14:1225759.

PMID: 37799971PMCID: PMC10549419

Memory discrimination is promoted by the expression of the transcription repressor WT1 in the dentate gyrus

Munari L, Patel V, Johnson N, Mariottini C, Prabha S, Blitzer RD, Iyengar R.

Front Behav Neurosci. 2023 Sep 27;17:1130840.

PMID: 37830039PMCID: PMC10565551

2022

A reference tissue atlas for the human kidney

Hansen J, Sealfon R, Menon R, Eadon MT, Lake BB, Steck B, Anjani K, Parikh S, Sigdel TK, Zhang G, Velickovic D, Barwinska D, Alexandrov T, Dobi D, Rashmi P, Otto EA, Rivera M, Rose MP, Anderton CR, Shapiro JP, Pamreddy A, Winfree S, Xiong Y, He Y, de Boer IH, Hodgin JB, Barisoni L, Naik AS, Sharma K, Sarwal MM, Zhang K, Himmelfarb J, Rovin B, El-Achkar TM, Laszik Z, He JC, Dagher PC, Valerius MT, Jain S, Satlin LM, Troyanskaya OG, Kretzler M, Iyengar R, Azeloglu EU; Kidney Precision Medicine Project.

Sci Adv. 2022 Jun 10;8(23):eabn4965.

PMID: 35675394PMCID: PMC9177149

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity

Xiong Y, Liu T, Chen T, Hansen J, Hu B, Chen Y, Jayaraman G, Schürer S, Vidovic D, Goldfarb J, Sobie EA, Birtwistle MR, Iyengar R, Li H, Azeloglu EU.

Sci Data. 2022 Jan 20;9(1):18.

PMID: 35058449PMCID: PMC8776882

New Views of Old Proteins: Clarifying the Enigmatic Proteome

Burnum-Johnson KE, Conrads TP, Drake RR, Herr AE, Iyengar R, Kelly RT, Lundberg E, MacCoss MJ, Naba A, Nolan GP, Pevzner PA, Rodland KD, Sechi S, Slavov N, Spraggins JM, Van Eyk JE, Vidal M, Vogel C, Walt DR, Kelleher NL.

Mol Cell Proteomics. 2022 Jul;21(7):100254.

PMID: 35654359PMCID: PMC9247754

Functional Effects of Cardiomyocyte Injury in COVID-19

Siddiq MM, Chan AT, Miorin L, Yadaw AS, Beaumont KG, Kehrer T, Cupic A, White KM, Tolentino RE, Hu B, Stern AD, Tavassoly I, Hansen J, Sebra R, Martinez P, Prabha S, Dubois N, Schaniel C, Iyengar-Kapuganti R, Kukar N, Giustino G, Sud K, Nirenberg S, Kovatch P, Albrecht RA, Goldfarb J, Croft L, McLaughlin MA, Argulian E, Lerakis S, Narula J, García-Sastre A, Iyengar R.

J Virol. 2022 Jan 26;96(2):e0106321.

PMID: 34669512PMCID: PMC8771960

Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors

Shim JV, Xiong Y, Dhanan P, Dariolli R, Azeloglu EU, Hu B, Jayaraman G, Schaniel C, Birtwistle MR, Iyengar R, Dubois NC, Sobie EA.

Front Pharmacol. 2023 Apr 10;14:1158222.

PMID: 37101545PMCID: PMC10123512

Relating individual cell division events to single-cell ERK and Akt activity time courses

Stern AD, Smith GR, Santos LC, Sarmah D, Zhang X, Lu X, Iuricich F, Pandey G, Iyengar R, Birtwistle MR.

Sci Rep. 2022 Oct 27;12(1):18077.

PMID: 36302844PMCID: PMC9613670

Whole cell response to receptor stimulation involves many deep and distributed subcellular biochemical processes

Hansen J, Siddiq MM, Yadaw AS, Tolentino RE, Rabinovich V, Jayaraman G, Jain MR, Liu T, Li H, Xiong Y, Goldfarb J, Iyengar R.

J Biol Chem. 2022 Oct;298(10):102325.

PMID: 35926710PMCID: PMC9530460

Fibrillin-1 deficiency in the outer perichondrium causes longitudinal bone overgrowth in mice with Marfan syndrome

Sedes L, Wondimu E, Crockett B, Hansen J, Cantalupo A, Asano K, Iyengar R, Rifkin DB, Smaldone S, Ramirez F.

Hum Mol Genet. 2022 Sep 29;31(19):3281-3289.

PMID: 35567544PMCID: PMC9520938

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals

Schaniel C, Dhanan P, Hu B, Xiong Y, Raghunandan T, Gonzalez DM, Dariolli R, D'Souza SL, Yadaw AS, Hansen J, Jayaraman G, Mathew B, Machado M, Berger SI, Tripodi J, Najfeld V, Garg J, Miller M, Surlyn CS, Michelis KC, Tangirala NC, Weerahandi H, Thomas DC, Beaumont KG, Sebra R, Mahajan M, Schadt E, Vidovic D, Schürer SC, Goldfarb J, Azeloglu EU, Birtwistle MR, Sobie EA, Kovacic JC, Dubois NC, Iyengar R.

Stem Cell Reports. 2021 Dec 14;16(12):3036-3049.

PMID: 34739849PMCID: PMC8683709

2021

Rationale and design of the Kidney Precision Medicine Project

de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O'Toole JF, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J; Kidney Precision Medicine Project.

Kidney Int. 2021 Mar;99(3):498-510.

PMID: 33637194PMCID: PMC7902500

Protein structure-based gene expression signatures

Rahman R, Zatorski N, Hansen J, Xiong Y, van Hasselt JGC, Sobie EA, Birtwistle MR, Azeloglu EU, Iyengar R, Schlessinger A.

Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2014866118.

PMID: 33941686PMCID: PMC8126780

2020

Clinical features of COVID-19 mortality: development and validation of a clinical prediction model

Arjun S Yadaw, Yan-Chak Li, Sonali Bose, Ravi Iyengar, Supinda Bunyavanich, Gaurav Pandey

Lancet Digit Health 2020 Oct;2(10):e516-e525

PMID: 32984797PMCID: PMC7508513

2019

Wilm's Tumor 1 Promotes Memory Flexibility

Chiara Mariottini, Leonardo Munari, Ellen Gunzel, Joseph M Seco, Nikos Tzavaras, Jens Hansen, Sarah A Stern, Virginia Gao, Hossein Aleyasin, Ali Sharma, Evren U Azeloglu, Georgia E Hodes , Scott J Russo , Vicki Huff , Marc R Birtwistle, Robert D Blitzer, Cristina M Alberini, Ravi Iyengar

Nat Commun. 2019 Aug 21;10(1):3756.

PMID: 31434897PMCID: PMC6704057

Geometric Principles of Second Messenger Dynamics in Dendritic Spines

Andrea Cugno, Thomas M Bartol, Terrence J Sejnowski, Ravi Iyengar, Padmini Rangamani

Sci Rep. 2019 Aug 12;9(1):1167.6

PMID: 31406140PMCID: PMC6691135

Genomic Signatures Defining Responsiveness to Allopurinol and Combination Therapy for Lung Cancer Identified by Systems Therapeutics Analyses

Iman Tavassoly, Yuan Hu, Shan Zhao, Chiara Mariottini, Aislyn Boran, Yibang Chen, Lisa Li, Rosa E Tolentino, Gomathi Jayaraman, Joseph Goldfarb, James Gallo, Ravi Iyengar

Mol Oncol. 2019 Aug;13(8):1725-1743.

PMID: 31116490PMCID: PMC6670022

Systems Pharmacology-Based Integration of Human and Mouse Data for Drug Repurposing to treat Thoracic Aneurysms

Jens Hansen, Josephine Galatioto, Cristina I Caescu, Pauline Arnaud, Rhodora C Calizo, Bart Spronck, Sae-Il Murtada, Roshan Borkar, Alan Weinberg, Evren U Azeloglu, Maria Bintanel-Morcillo, James M Gallo, Jay D Humphrey, Guillaume Jondeau, Catherine Boileau, Francesco Ramirez, Ravi Iyengar

JCI Insight. 2019 Jun 6;4(11):e127652.

PMID: 31167969PMCID: PMC6629138

Dynamic Balance Between Vesicle Transport and Microtubule Growth Enables Neurite Outgrowth

Arjun Singh Yadaw , Mustafa M Siddiq , Vera Rabinovich , Rosa Tolentino , Jens Hansen , Ravi Iyengar

PLoS Comput Biol. 2019 May 1;15(5):e1006877.

PMID: 31042702PMCID: PMC6546251

OSCI: Standardized Stem Cell Ontology Representation and Use Cases for Stem Cell Investigation

Yongqun He, William D Duncan, Daniel J Cooper, Jens Hansen, Ravi Iyengar, Edison Ong, Kendal Walker, Omar Tibi, Sam Smith, Lucas M Serra, Jie Zheng, Sirarat Sarntivijai, Stephan Schürer, K Sue O'Shea, Alexander D Diehl

BMC Bioinformatics. 2019 Apr 25;20(Suppl 5):180.

PMID: 31272389PMCID: PMC6509805

Systems Pharmacology: Defining the Interactions of Drug Combinations

J G Coen van Hasselt, Ravi Iyengar

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:21-40.

PMID: 30260737

2018

Systems Biology Primer: The Basic Methods and Approaches

Iman Tavassoly, Joseph Goldfarb, Ravi Iyengar

Essays Biochem. 2018 Oct 26;62(4):487-500.

PMID: 30287586

Validating Antibodies for Quantitative Western Blot Measurements With Microwestern Array

Rick J Koch, Anne Marie Barrette, Alan D Stern, Bin Hu, Mehdi Bouhaddou, Evren U Azeloglu, Ravi Iyengar, Marc R Birtwistle

Sci Rep. 2018 Jul 27;8(1):11329.

PMID: 30054510PMCID: PMC6063895

Cell Type-Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease-Brief Report

Galatioto J, Caescu CI, Hansen J, Cook JR, Miramontes I, Iyengar R, Ramirez F.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):588-591.

PMID: 29371244PMCID: PMC5823778

LATEST WORKS

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