_Publications

Publications

2020


Clinical Predictors of COVID-19 Mortality.

Arjun S Yadaw, Yan-Chak Li, Sonali Bose, Ravi Iyengar, Supinda Bunyavanich, Gaurav Pandey
medRxiv. 2020 May 22:2020.05.19.20103036.
PMID: 32511520 | PMCID: PMC7273288


2019


Wilm's Tumor 1 Promotes Memory Flexibility

Chiara Mariottini, Leonardo Munari, Ellen Gunzel, Joseph M Seco, Nikos Tzavaras, Jens Hansen, Sarah A Stern, Virginia Gao, Hossein Aleyasin, Ali Sharma, Evren U Azeloglu, Georgia E Hodes , Scott J Russo , Vicki Huff , Marc R Birtwistle, Robert D Blitzer, Cristina M Alberini, Ravi Iyengar
Nat Commun. 2019 Aug 21;10(1):3756.
PMID: 31434897 | PMCID: PMC6704057

Geometric Principles of Second Messenger Dynamics in Dendritic Spines

Andrea Cugno, Thomas M Bartol, Terrence J Sejnowski, Ravi Iyengar, Padmini Rangamani
Sci Rep. 2019 Aug 12;9(1):1167.6
PMID: 31406140 | PMCID: PMC6691135

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines

Mario Niepel, Marc Hafner, Caitlin E Mills, Kartik Subramanian, Elizabeth H Williams, Mirra Chung, Benjamin Gaudio, Anne Marie Barrette, Alan D Stern, Bin Hu, James E Korkola, LINCS Consortium; Joe W Gray, Marc R Birtwistle, Laura M Heiser, Peter K Sorger
Cell Syst. 2019 Jul 24;9(1):35-48.e5.
PMID: 31302153 | PMCID: PMC6700527 (available on 2020-07-24)

Genomic Signatures Defining Responsiveness to Allopurinol and Combination Therapy for Lung Cancer Identified by Systems Therapeutics Analyses

Iman Tavassoly, Yuan Hu, Shan Zhao, Chiara Mariottini, Aislyn Boran, Yibang Chen, Lisa Li, Rosa E Tolentino, Gomathi Jayaraman, Joseph Goldfarb, James Gallo, Ravi Iyengar
Mol Oncol. 2019 Aug;13(8):1725-1743.
PMID: 31116490 | PMCID: PMC6670022

Systems Pharmacology-Based Integration of Human and Mouse Data for Drug Repurposing to Treat Thoracic Aneurysms

Jens Hansen, Josephine Galatioto, Cristina I Caescu, Pauline Arnaud, Rhodora C Calizo, Bart Spronck, Sae-Il Murtada, Roshan Borkar, Alan Weinberg, Evren U Azeloglu, Maria Bintanel-Morcillo, James M Gallo, Jay D Humphrey, Guillaume Jondeau, Catherine Boileau, Francesco Ramirez, Ravi Iyengar
JCI Insight. 2019 Jun 6;4(11):e127652.
PMID: 31167969 | PMCID: PMC6629138

Dynamic Balance Between Vesicle Transport and Microtubule Growth Enables Neurite Outgrowth

Arjun Singh Yadaw , Mustafa M Siddiq , Vera Rabinovich , Rosa Tolentino , Jens Hansen , Ravi Iyengar
PLoS Comput Biol. 2019 May 1;15(5):e1006877.
PMID: 31042702 | PMCID: PMC6546251

OSCI: Standardized Stem Cell Ontology Representation and Use Cases for Stem Cell Investigation

Yongqun He, William D Duncan, Daniel J Cooper, Jens Hansen, Ravi Iyengar, Edison Ong, Kendal Walker, Omar Tibi, Sam Smith, Lucas M Serra, Jie Zheng, Sirarat Sarntivijai, Stephan Schürer, K Sue O'Shea, Alexander D Diehl
BMC Bioinformatics. 2019 Apr 25;20(Suppl 5):180.
PMID: 31272389 | PMCID: PMC6509805

Systems Pharmacology: Defining the Interactions of Drug Combinations

J G Coen van Hasselt, Ravi Iyengar
Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:21-40.
PMID: 30260737


2018


Systems Biology Primer: The Basic Methods and Approaches

Iman Tavassoly, Joseph Goldfarb, Ravi Iyengar
Essays Biochem. 2018 Oct 26;62(4):487-500.
PMID: 30287586

Validating Antibodies for Quantitative Western Blot Measurements With Microwestern Array

Rick J Koch, Anne Marie Barrette, Alan D Stern, Bin Hu, Mehdi Bouhaddou, Evren U Azeloglu, Ravi Iyengar, Marc R Birtwistle
Sci Rep. 2018 Jul 27;8(1):11329.
PMID: 30054510 | PMCID: PMC6063895

Cell Type-Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease-Brief Report

Iman Tavassoly, Joseph Goldfarb, Ravi Iyengar
Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):588-591.
PMID: 29371244 | PMCID: PMC5823778

Preprints on biorxiv

Protein structure-based gene expression signatures

R. Rahman, Y. Xiong, J. G. C. van Hasselt, J. Hansen, E. A. Sobie, M. R. Birtwistle, E. Azeloglu, R. Iyengar, A. Schlessinger

A tissue- and organ-based cell biological atlas of obesity-related human genes and cellular pathways

Iman Tavassoly, Valentina Barbieri, Coen van Hasselt, Pedro Martinez, Eric A. Sobie, Jens Hansen, Evren Azeloglu, Joseph Goldfarb, Philippe Sanseau, Deepak K Rajpal, Ravi Iyengar

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset

Yuguang Xiong, Tong Liu, Tong Chen, Jens Hansen, Bin Hu, Yibang Chen, Gomathi Jayaraman, Stephan Schürer, Dusica Vidovic, Joseph Goldfarb, Eric A. Sobie, Marc R. Birtwistle, Ravi Iyengar, Hong Li, Evren U. Azeloglu

Whole cell response to receptor stimulation involves many deep and distributed subcellular processes

Jens Hansen, Arjun Singh Yadaw, Mustafa M. Siddiq, Rosa Tolentino, Vera Rabinovich, Gomathi Jayaraman, Mohit Jain, Tong Liu, Hong Li, Joseph Goldfarb, Ravi Iyengar

Cell shape regulates subcellular organelle location to control short-term Ca2+ signal dynamics in VSMC

Rhodora C. Calizo, Amit Ron, Mufeng Hu, Smiti Bhattacharya, William G.M. Janssen, James Hone, Suzanne Scarlata, Padmini Rangamani, Ravi Iyengar

Drug combinations targeting multiple cellular mechanisms enable axonal regeneration from crushed optic nerve into the brain

Mustafa M. Siddiq, Yana Zorina, Arjun Singh Yadaw, Jens Hansen, Vera Rabinovich, Sarah M. Gregorich, Yuguang Xiong, Rosa E. Tolentino, Sari S. Hannila, Ehud Kaplan, Robert D. Blitzer, Marie T. Filbin, Christopher L. Passaglia, Ravi Iyengar

Activated Protein C blocks the inhibitory effect on neurite outgrowth by extracellular histones that mediates its inhibition through a retrograde YB-1 signal

Mustafa M. Siddiq, Sari S. Hannila, Yana Zorina, Elena Nikulina, Vera Rabinovich, Jianwei Hou, Rumana Huq, Erica L. Richman, Rosa E. Tolentino, Stella E. Tsirka, Ian Maze, Ravi Iyengar, Marie T. Filbin

Fragile dynamics enable diverse genomic determinants to influence arrhythmia propensity

Tim J Kamerzell, Eric A Sobie, Kai-Chen Yang, Jeanne M Nerbonne, Calum A MacRae, Ravi Iyengar

Clinically-weighted transcriptomic signatures for protein kinase inhibitor associated cardiotoxicity

JGC van Hasselt, J Hansen, Y Xiong, J Shim, A Pickard, G Jayaraman, B Hu, M Mahajan, J Gallo, EA Sobie, MR Birtwistle, EU Azeloglu, R Iyengar