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Scientific Discovery Visualization
SCIENTIFIC IMPACT

KEY DISCOVERIES

FOUNDATION 01

Divalent cations regulate G protein activation to facilitate receptor stimulation

Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides.

Iyengar R, Birnbaumer L.
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5179-83.
1982

Hysteretic activation of adenylyl cyclases. II. Mg ion regulation of the activation of the regulatory component as analyzed by reconstitution

Iyengar R.
J Biol Chem. 1981 Nov 10;256(21):11042-50.
1981

Hysteretic activation of adenylyl cyclases. I. Effect of Mg ion on the rate of activation by guanine nucleotides and fluoride.

Iyengar R, Birnbaumer L.
J Biol Chem. 1981 Nov 10;256(21):11036-41.
1981
FOUNDATION 02

Activated G protein –α subunits function as oncogenes

Enhanced phospholipase C stimulation and transformation in NIH-3T3 cells expressing Q209LGq-alpha-subunits.

De Vivo M, Chen J, Codina J, Iyengar R.
J Biol Chem. 1992 Sep 15;267(26):18263-6.
1992

The Q205LGo-alpha subunit expressed in NIH-3T3 cells induces transformation.

Kroll SD, Chen J, De Vivo M, Carty DJ, Buku A, Premont RT, Iyengar R.
J Biol Chem. 1992 Nov 15;267(32):23183-8.
1992
FOUNDATION 03

Adenylyl cyclase isoforms both sort and integrate signals from different receptors thus enabling the formation of cAMP signaling networks.

Two members of a widely expressed subfamily of Hormone Stimulated Adenylyl Cyclases

Premont R. T., Chen, J., Ma H-W, Ponnapalli, M., and Iyengar R.
Proc. Natl. Acad. Sci. USA 89: 9809-9813.
1992

Signal recognition and integration by Gs-stimulated adenylyl cyclases.

Pieroni JP, Jacobowitz O, Chen J, Iyengar R.
Curr Opin Neurobiol. 1993 Jun;3(3):345-51. Review.
1993

Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2.

Jacobowitz O, Iyengar R.
Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10630-4.
1994
FOUNDATION 04

Interacting signaling networks process and store information.

Gating by cAMP: Expanded Role for an Old Signaling Pathway.

Iyengar R.
Science 271:461-463
1996

Gating of CaMKII by cAMP Regulated Phosphatase Phosphatase Activity During LTP.

Blitzer R. D., Connor J. H., Brown G. P, Wong T, Shenolikar S., Iyengar R, and Landau E. M.
Science 280:1940-1943.
1998

Emergent Properties of Networks of Biological Signaling Pathways.

Bhalla U. S, Iyengar R
Science 283: 381-387.
1999

MAP-kinase phosphatase as a Locus of Flexibility in a MAP-kinase Signaling Network

Bhalla, U. S., Ram P. T., Iyengar R
Science 297: 1018-1023.
2002

Formation of regulatory patterns during propagation of signal induced connectivity in a mammalian neuronal cellular network.

Ma’ayan A., Jenkins S.L., Neves, S., Hasseldine H., Grace, E, Dubin-Thaler, B, Eungdamrong N. J. , Weng G., Ram P. T., Rice J. J. Kershenbaum, A. Stolovitzky G. A. Blitzer R. D. and Iyengar R.
Science 309: 1078-1083.
2005

Design Logic of a cannabinoid receptor signaling network that triggers neurite outgrowth.

Bromberg K.D., Maayan A., Neves S.R. and Iyengar R
Science ;320 :903-9.
2008

Interconnected network motifs control podocyte morphology and kidney function.

Mazeloglu EU, Hardy SV, Eungdamrong NJ, Chen Y, Jayaraman G, Chuang PY, Fang W, Xiong H, Neves SR, Jain MR, Li H, Ma'ayan A, Gordon RE, He JC, Iyengar R.
Sci Signal. 2014 Feb 4;7(311): ra12.
2014
FOUNDATION 05

Cell shape controls information flow and is a source of biological information

Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks.

Neves S.R, Tsokas P., Sarkar A., Grace E. A., Rangamani P, Taubenfeld S. M. , Alberini C.M. , Schaff J. C., Blitzer R. D. , Moraru I.I. , and Iyengar R.
Cell 133:666-680.
2008

Decoding information in cell shape.

Rangamani P, Lipshtat A, Azeloglu EU, Calizo RC, Hu M, Ghassemi S, Hone J, Scarlata S, Neves SR, Iyengar R.
Cell,154:1356-69.
2013

Cell shape information is transduced through tension-independent mechanisms.

Ron A, Azeloglu EU, Calizo RC, Hu M, Bhattacharya S, Chen Y, Jayaraman G, Lee S, Neves-Zaph SR, Li H, Gordon RE, He JC, Hone JC, Iyengar R.
Nat Commun. 2017 Dec 15;8(1):2145.
2017
FOUNDATION 06

Analysis of cellular regulatory networks identifies drug therapy for complex diseases

Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms.

Hansen,J, Galatioto J, Caescu CI, Arnaud P Calizo RC, Spronck B , Murtada SI, Roshan Borkar R , Azeloglu EA, Bintanel-Morcillo M, Gallo, JM, . HumphreyJD, Jondeau G Catherine Boileau C, Ramirez F and Iyengar R.
JCI Insight. 2019 Jun 6;4(11):e127652.
2019

Systems therapeutics analyses identify genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer.

Tavassoly I , Hu H , Zhao S , Mariottini C, Boran A , Chen YB, Li Lisa, Tolentino RE, Jayaraman G , Goldfarb G , Gallo JM ,Iyengar R.
Mol Oncol. 2019 Aug;13(8):1725-1743.
2019

Drug Combinations targeting multiple cellular mechanisms enable axonal regeneration from crushed optic nerve into the brain.

Siddiq MM, Zorina Y, Yadaw A, Hansen J, Rabinovich R, Gregorich SM, Xiong Y, Tolentino RE, Hannila, S, Kaplan E, Blitzer RD, Filbin, MT Passaglia CL, Iyengar R.
bioRxiv 157099.
2017