_Discoveries

Key discoveries in the Iyengar laboratory

Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides.

Iyengar R, Birnbaumer L.
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5179-83.

Hysteretic activation of adenylyl cyclases. II. Mg ion regulation of the activation of the regulatory component as analyzed by reconstitution

Iyengar R.
J Biol Chem. 1981 Nov 10;256(21):11042-50.

Hysteretic activation of adenylyl cyclases. I. Effect of Mg ion on the rate of activation by guanine nucleotides and fluoride.

Iyengar R, Birnbaumer L.
J Biol Chem. 1981 Nov 10;256(21):11036-41.

Enhanced phospholipase C stimulation and transformation in NIH-3T3 cells expressing Q209LGq-alpha-subunits.

De Vivo M, Chen J, Codina J, Iyengar R.
J Biol Chem. 1992 Sep 15;267(26):18263-6.

The Q205LGo-alpha subunit expressed in NIH-3T3 cells induces transformation.

Kroll SD, Chen J, De Vivo M, Carty DJ, Buku A, Premont RT, Iyengar R.
J Biol Chem. 1992 Nov 15;267(32):23183-8.

Two members of a widely expressed subfamily of Hormone Stimulated Adenylyl Cyclases

Premont R. T., Chen, J., Ma H-W, Ponnapalli, M., and Iyengar R. (1992)
Proc. Natl. Acad. Sci. USA 89: 9809-9813.

Signal recognition and integration by Gs-stimulated adenylyl cyclases.

Pieroni JP, Jacobowitz O, Chen J, Iyengar R. (1993)
Curr Opin Neurobiol. 1993 Jun;3(3):345-51. Review.

Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2.

Jacobowitz O, Iyengar R.
Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10630-4.

Gating by cAMP: Expanded Role for an Old Signaling Pathway.

Iyengar R. (1996)
Science 271:461-463

Gating of CaMKII by cAMP Regulated Phosphatase Phosphatase Activity During LTP.

Blitzer R. D., Connor J. H., Brown G. P, Wong T, Shenolikar S., Iyengar R, and Landau E. M. (1998)
Science 280:1940-1943.

Emergent Properties of Networks of Biological Signaling Pathways.

Bhalla U. S, Iyengar R (1999)
Science 283: 381-387.

MAP-kinase phosphatase as a Locus of Flexibility in a MAP-kinase Signaling Network

Bhalla, U. S., Ram P. T., Iyengar R (2002)
Science 297: 1018-1023.

Formation of regulatory patterns during propagation of signal induced connectivity in a mammalian neuronal cellular network.

Ma’ayan A., Jenkins S.L., Neves, S., Hasseldine H., Grace, E, Dubin-Thaler, B, Eungdamrong N. J. , Weng G., Ram P. T., Rice J. J. Kershenbaum, A. Stolovitzky G. A. Blitzer R. D. and Iyengar R. (2005)
Science 309: 1078-1083.

Design Logic of a cannabinoid receptor signaling network that triggers neurite outgrowth.

Bromberg K.D., Maayan A., Neves S.R. and Iyengar R (2008)
Science ;320 :903-9.

Interconnected network motifs control podocyte morphology and kidney function.

MAzeloglu EU, Hardy SV, Eungdamrong NJ, Chen Y, Jayaraman G, Chuang PY, Fang W, Xiong H, Neves SR, Jain MR, Li H, Ma'ayan A, Gordon RE, He JC, Iyengar R. (2014)
Sci Signal. 2014 Feb 4;7(311): ra12. doi:10.1126/scisignal.2004621.

Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks.

Neves S.R, Tsokas P., Sarkar A., Grace E. A., Rangamani P, Taubenfeld S. M. , Alberini C.M. , Schaff J. C., Blitzer R. D. , Moraru I.I. , and Iyengar R. (2008)
Cell 133:666-680.

Decoding information in cell shape.

Rangamani P, Lipshtat A, Azeloglu EU, Calizo RC, Hu M, Ghassemi S, Hone J, Scarlata S, Neves SR, Iyengar R. (2013)
Cell,154:1356-69.

Cell shape information is transduced through tension-independent mechanisms.

Ron A, Azeloglu EU, Calizo RC, Hu M, Bhattacharya S, Chen Y, Jayaraman G, Lee S, Neves-Zaph SR, Li H, Gordon RE, He JC, Hone JC, Iyengar R.
Nat Commun. 2017 Dec 15;8(1):2145. doi: 10.1038/s41467-017-02218-4.

Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms.

Hansen,J, Galatioto J, Caescu CI, Arnaud P Calizo RC, Spronck B , Murtada SI, Roshan Borkar R , Azeloglu EA, Bintanel-Morcillo M, Gallo, JM, . HumphreyJD, Jondeau G Catherine Boileau C, Ramirez F and Iyengar R.
JCI Insight submitted

Systems therapeutics analyses identify genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer.

Tavassoly I , Hu H , Zhao S , Mariottini C, Boran A , Chen YB, Li Lisa, Tolentino RE, Jayaraman G , Goldfarb G , Gallo JM ,Iyengar R.
bioRxiv 396697.

Drug Combinations targeting multiple cellular mechanisms enable axonal regeneration from crushed optic nerve into the brain.

Siddiq MM, Zorina Y, Yadaw A, Hansen J, Rabinovich R, Gregorich SM, Xiong Y, Tolentino RE, Hannila, S, Kaplan E, Blitzer RD, Filbin, MT Passaglia CL, Iyengar R.
bioRxiv 157099.