We are a systems biology and systems pharmacology laboratory. We use systems reasoning to address fundamental questions in mammalian biology, biomedicine, and pharmacology. Our long-standing expertise is in the biochemistry and molecular biology of cell signaling pathways and networks, especially G protein pathways. We have expertise in many experimental and computational methodologies.Learn More
Patients with COVID-19 showed multiple pathophysiologies including heart kidney and clotting dysfunctions in addition to pneumonia. We do not understand the mechanisms for these varied responses. We are using single cell transcriptomic data from different human cell types representing the different organs and clinical and whole genome sequencing data from COVID-19 patients to identify genomic characteristics of susceptibility to multi-organ dysfunction.Learn More
For over two decades we have studied, both experimentally and computationally, how interactions among cell signaling networks within neurons regulate neuronal plasticity,. As part of these studies we found that memory formation processes activate transcriptional repressors that enable forgetting. We are now studying the molecular pathways and the cellular circuits within the hippocampus involved in forgetting and are determining the role of regulatory loops, such as feedforward loops, in controlling the balance between remembering and forgetting.Learn More
Chiara Mariottini, Leonardo Munari, Ellen Gunzel, Joseph M Seco, Nikos Tzavaras, Jens Hansen, Sarah A Stern, Virginia Gao, Hossein Aleyasin, Ali Sharma, Evren U Azeloglu, Georgia E Hodes , Scott J Russo , Vicki Huff , Marc R Birtwistle, Robert D Blitzer, Cristina M Alberini, Ravi Iyengar
Nat Commun. 2019 Aug 21;10(1):3756.