PREDICTOX
ENVIRONMENT
Multiscale Capability for Adverse Event Predictions
A comprehensive systems biology knowledge environment for predicting drug-induced adverse events. predicTox integrates transcriptomic signatures with clinical data to unlock predictive toxicology at the individual level.
STEM CELL
REPORTS
A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals could serve as a useful resource of normal controls for in vitro human development.
Impact Factor
7.3
Citations
412
Systems reasoning for
human physiology
We use systems reasoning to address fundamental questions in mammalian biology, biomedicine, and pharmacology. Our expertise spans from G protein signaling to large-scale computational methodologies.
Methodology & FacilitiesMulti-scale analysis and computational modeling
Multi-organ Susceptibility
in COVID-19
Identifying clinical cohorts and genomic characteristics of systemic failure through single-cell transcriptomic sequencing.
Forgetting
For over two decades we have studied how interactions among cell signaling networks within neurons regulate neuronal plasticity. We found that memory formation processes activate transcriptional repressors that enable forgetting.
Scholarly Impact
25k+
Total Citations
LATEST PUBLICATIONS
Protein structure-based gene expression signatures.
Rahman R, Zatorski N, Hansen J, Xiong Y, et al.
Proc Natl Acad Sci U S A
2021 May
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Caescu CI, Hansen J, Crockett B, et al.
Arterioscler Thromb Vasc Biol
2021 Sep
The Human ApoE4 Variant Reduces Functional Recovery and Neuronal Sprouting After Incomplete Spinal Cord Injury.
Toro CA, Hansen J, Siddiq MM, et al.
Front Cell Neurosci.
2021 Feb