Stem Cell Reports

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals

A library of well-characterized human induced pluripotent stem cell (hiPSC) lines from clinically healthy human subjects could serve as a useful resource of normal controls for in vitro human development, disease modeling, genotype-phenotype association studies, and drug response evaluation. Abstract


We are a systems biology and systems pharmacology laboratory. We use systems reasoning to address fundamental questions in mammalian biology, biomedicine, and pharmacology. Our long-standing expertise is in the biochemistry and molecular biology of cell signaling pathways and networks, especially G protein pathways. We have expertise in many experimental and computational methodologies.

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Multi organ pathophysiology in COVID -19

Patients with COVID-19 showed multiple pathophysiologies including heart kidney and clotting dysfunctions in addition to pneumonia. We do not understand the mechanisms for these varied responses. We are using single cell transcriptomic data from different human cell types representing the different organs and clinical and whole genome sequencing data from COVID-19 patients to identify genomic characteristics of susceptibility to multi-organ dysfunction.

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For over two decades we have studied, both experimentally and computationally, how interactions among cell signaling networks within neurons regulate neuronal plasticity,. As part of these studies we found that memory formation processes activate transcriptional repressors that enable forgetting. We are now studying the molecular pathways and the cellular circuits within the hippocampus involved in forgetting and are determining the role of regulatory loops, such as feedforward loops, in controlling the balance between remembering and forgetting.

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